Global Target Analysis
- Written by Chavdar Slavov
Global target analysis (GTA) is the more general case of global analysis, where kinetic models are directly tested for compliance with the time-resolved data. GTA is essential, because kinetic modeling is the only quantitative way to reveal reaction mechanisms. In essence, GTA consists of devising a kinetic reaction scheme based on previous knowledge about the studied system and certain assumptions. The kinetic scheme is then represented by a system of differential equations. The solution of such a system of differential equations for first-order kinetics is a sum-of-exponentials function similar to the one used in GLA, with the difference that now the lifetimes depend in a complex manner, defined by the kinetic model, on the kinetic rates. An important parameter that emerges from GTA is the species-associated spectrum (SAS), which physically represents the stationary spectra of the model compartments as if they were measured separately.
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